Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin.
نویسندگان
چکیده
A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 3 شماره
صفحات -
تاریخ انتشار 2011